A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells.However, CRISPR-based HIV excision is vulnerable to viral escape.Targeting cellular co-factors provides an attractive yet risky alternative to render viral escape irrelevant.Cyclin T1 is a

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Social contact and attitudes toward outsiders: The case of Japan

Previous studies have shown Keyboard Overlay that people oppose refugee resettlement more strongly after being exposed to frames that depict refugees as threatening.However, all people may not perceive such threats the same way.Based on contact theory, we hypothesize that the treatment effects of threatening frames on people’s opposition to refug

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